Caged Nicotinic Acid Adenine Dinucleotide Phosphate
نویسندگان
چکیده
منابع مشابه
Nicotinic acid adenine dinucleotide phosphate (NAADP+).
Microinjection of human Jurkat T-lymphocytes with nicotinic acid adenine dinucleotide phosphate (NAADP 1 ) dose-dependently stimulated intracellular Ca 2 1 -signaling. At a concentration of 10 nM NAADP 1 evoked repetitive and long-lasting Ca 2 1 oscillations of low amplitude, whereas at 50 and 100 nM, a rapid and high initial Ca 2 1 -peak followed by trains of smaller Ca 2 1 -oscillations was o...
متن کاملNicotinic Acid Adenine Dinucleotide Phosphate (NAADP
Microinjection of human Jurkat T-lymphocytes with nicotinic acid adenine dinucleotide phosphate (NAADP 1 ) dose-dependently stimulated intracellular Ca 2 1 -signaling. At a concentration of 10 nM NAADP 1 evoked repetitive and long-lasting Ca 2 1 oscillations of low amplitude, whereas at 50 and 100 nM, a rapid and high initial Ca 2 1 -peak followed by trains of smaller Ca 2 1 -oscillations was o...
متن کاملDetermination of cellular nicotinic acid-adenine dinucleotide phosphate (NAADP) levels.
Nicotinic acid-adenine dinucleotide phosphate (NAADP) is fast emerging as a new intracellular Ca2+-mobilizing messenger. In sea urchin egg homogenates, binding of NAADP to its receptor is not readily reversible; hence, prior incubation with low concentrations of NAADP is more effective in inhibiting subsequent binding of radiolabelled NAADP than incubating the preparation with the two ligands s...
متن کاملNicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-mediated Calcium Signaling*
Nicotinic acid adenine dinucleotide phosphate (NAADP)2 is a metabolite of NADP that was first identified as the most potent Ca2 stores mobilizing molecule in sea urchin egg homogenates more than a decade ago (1, 2). It has since been shown to be effective in a wide variety of cells, from plant to animal, including human (reviewed in Refs. 3–5). Its mechanism of action is distinct from those of ...
متن کاملNicotinic acid adenine dinucleotide phosphate: a new intracellular second messenger?
Nicotinic acid adenine dinucleotide phosphate (NAADP) is one of the most potent stimulators of intracellular Ca2+ release known to date. The role of the NAADP system in physiological processes is being extensively investigated at the present time. Exciting new discoveries in the last 5 years suggest that the NAADP-regulated system may have a significant role in intracellular Ca2+ signaling. The...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1997
ISSN: 0021-9258
DOI: 10.1074/jbc.272.7.4172